Pharmaceutical Chemicals API (267)
Showing 169–180 of 267 products · Page 15 of 23
Naproxen Sodium 26159-34- 2 Sodiumnaprosyn
It is commonly used for the reduction of pain, fever, inflammation, and stiffness caused by conditions including migraine, osteoarthritis,kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, and bursitis, among others. It is also used for the treatment of primary dysmenorrhea.
Narasin
Narasin is a tricyclic antidepressant (TCA), but it has different pharmacological properties than typical TCAs as recent research
Nicarbazine
Nicarbazine is a broad spectrum coccidiostat. Its inhibitory action occurs on second-generation schizonts(day 4 in the life cycle) ,so it does not easily develop resistance. It has been approved for prevention and control of coccidiosis in many countries.
Nicergoline
1-methyl-lumilysergol8-(5-bromonicotinate)10-methylether
Niclosamide
Niclosamide (trade name Niclocide) is a teniacide in the anthelmintic family especially effective against cestodes that infect humans and many other animals. It is a salicylanilide compound (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydrobenzamide) also used as a piscicide.
Nilotinib
Tasigna is a new kind of tumor targeting drug, which belongs to tyrosine kinase inhibitor. It is used to treat CML patients resistant to imatinib, and has a significant effect. Gleevec is a preferred drug developed by Novartis for the treatment of chronic myelogenous leukemia (CML). Nilotinib is improved from the molecular structure of imatinib, which has a stronger selectivity for bcr-abl kinase activity, a stronger inhibition of tyrosine kinase than imatinib by 30 times, and can inhibit the BCR-ABL mutant kinase activity resistant to imatinib. It can also inhibit the activity of kit and PDGFR kinase.
Nimustine Hydrochloride
Nimostine hydrochloride is a kind of pyrimidine nitrosourea anti-tumor drug. It is the main drug for the treatment of intracranial tumor and meningeal leukemia with other nitrosourea drugs, such as ramustine, carmustine, smeustine, lomustine, formustine, and estraustine sodium phosphate. It belongs to nitrosourea alkylating agent. It can alkylate DNA, prevent DNA repair, change RNA structure and target fine The structure and function of the protein and enzyme of the cell play an anti-tumor role. It can pass through the blood-brain barrier. Animal experiments showed that 7% - 16% of them entered CSF after intravenous drip, and the highest was 30%. After intravenous drip for 5 minutes, the drug began to distribute in the ventricles. After 30 minutes, the drug concentration in the cerebrospinal fluid reached the peak value with a half-life of 0.49 hours. Clinically, it can be used to treat brain tumor, lung cancer, gastric cancer, rectal cancer, esophageal cancer, colon cancer, chronic leukemia and lymphoma, etc. it can be used in combination with other anti-tumor drugs.
Nisoldipine
Nisoldipine (INN) is a calcium channel blocker of the dihydropyridine class. It sold in the United Statesunder the proprietary name Sular. Nisoldipine has tropism for cardiac blood vessels.
Norfloxacin
Norfloxacin has broad-spectrum and high-efficiency antimicrobial effect, wide treatment range, good oral absorption, low toxicity. It is mainly used in the treatment of urinary tract infection, biliary tract infection and intestinal infection in clinic, with remarkable curative effect.It is suitable for urinary tract infection, gonorrhea, prostatitis, intestinal infection, typhoid fever and other Salmonella infections. Antibiotics, used in the treatment of upper respiratory tract infections, urinary and gastrointestinal tract bacterial infections, biliary tract, surgery, gynecology and obstetrics and other infections have a better effect.
Octreotide
Octreotide is a kind of synthetic octapeptide ring compound used in digestive system. It is a homologue of natural somatostatin, has the pharmacological activity of natural somatostatin, and has long-term effect (the half-life of this product is 1.5 hours, and the natural somatostatin is 2-3 minutes). This product has selective inhibitory effect on the secretion of growth hormone, glucagon and insulin, which is stronger than natural somatostatin. The animal test shows that the inhibitory effect of this product on the release of growth hormone is 70 times of natural somatostatin and the inhibitory effect on insulin is 3 times of natural somatostatin after 15 minutes of intravenous injection. It can also inhibit the secretion of gastric acid, amylase, lipase and pepsin. It can slow down the passage time of the gastrointestinal tract, promote the absorption of water and electrolyte, have the contractive effect on the visceral blood vessels, reduce the visceral blood flow, reduce the blood flow of the liver, reduce the portal pressure and blood flow of the portal vein, reduce the excessive secretion of the intestinal tract, and enhance the absorption of water and Na + by the intestinal tract.
Ofloxacin Hydrochloride
Ofloxacin is used to treat infections including: respiratory tract infections,cellulitis,urinary tract infections,prostatitis, anthrax,endocarditis,meningitis,pelvic inflammatory disease,traveler's diarrhea,tuberculosis andplague.
Olaparib
Olapani is a new oral poly ADP ribose polymerase (PARP) inhibitor. PARP includes the most important members of three protein families: PARP1, PARP2 and parp3. PARP enzymes are involved in normal cell homeostasis, such as DNA transcription, cell cycle regulation and DNA repair. The results of olaparine in vitro showed that the single drug treatment or platinum based chemotherapy could inhibit the growth of the selected tumor cell line and the tumor growth of human cancer mice xenotransplantation model. The cytotoxicity and antitumor activity of BRCA deficient mouse tumor cell lines were increased after treatment with olaparine. In vitro studies also showed that the cytotoxicity induced by olapamil may be related to the inhibition of PARP enzyme activity and the increase of parp-dna complex formation, leading to the destruction of cell dynamic balance and cell death.
