Antineoplastic Drugs API (75)
Showing 1–12 of 75 products · Page 1 of 7
10-Hydroxycamptothecin
Exemestane is an irreversible steroidal aromatase inhibitors, has similar structure with its substrate,natural androstenedione. And it is the pseudo substrate of aromatase . The inhibition of aromatase to estrogen deprivation is a effective method in the treatment of postmenopausal women with hormone dependent breast cancer.
5-Fluorouracil
5- fluorouracil, referred to as fluorouracil for short, is a pyrimidine anti metabolism drug. It is a commonly used chemotherapeutic drug in clinic at present. It has an effect on all stages of proliferation, can prevent the formation of thymine, inhibit the biosynthesis of DNA, and thus inhibit the growth of cancer cells. It is used in the treatment of digestive tract tumors, such as gastric cancer, colorectal cancer, liver cancer, etc. It is also effective for breast cancer, ovarian cancer, lung cancer, bladder cancer, cervical cancer, pancreatic cancer, etc. The cancer treatment cream produced in Switzerland contains 5% of this product. It is mainly used for actinic keratosis and senile keratosis, precancerous dermatitis, single and multiple superficial basal cell carcinoma, cancer stage and superficial basal cell carcinoma after radiation skin disease damage.
Adriamycin
Adriamycin, also known as 14-hydroxy-positive-amicin, 14-hydroxy-daunorubicin, doxorubicin, adriamycin, adriamycin, and hydroxyrubicin, is an anthracycline anti-tumor antibiotic produced by the subspecies of Streptomyces bosaiensis, which is a non-specific drug in cell cycle and sensitive to s and M phases. The hydrochloride is orange needle crystal. Melting point 204-205 ℃. Soluble in water, ethanol and methanol. The aqueous solution is stable, and it will not change for one month when it is placed at 5 ℃, but it is unstable when it is higher temperature or in acid or alkaline solution. The acid solution is orange yellow, the neutral solution is orange chemical book red, and the alkaline solution is purple blue (pH > 9). Insoluble in acetone, benzene, petroleum ether, ether, chloroform. It is an antineoplastic antibiotic isolated from actinomycetes. The mechanism of action is similar to daunorubicin. Its antitumor spectrum is wide and its therapeutic index is high.
Afatinib
Afatinib is a potent and irreversible dual inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor 2 tyrosine kinase. This product is suitable for the treatment of the following patients: 1. Local advanced or metastatic non-small cell lung cancer with EGFR receptor gene sensitive mutation, 2. Local advanced or metastatic squamous cell lung cancer without EGFR tyrosine kinase inhibitor treatment during or after chemotherapy with platinum.
Anastrozole
Anatrazole is a powerful selective triazole aromatase inhibitor. It can inhibit the aromatase dependent on cytochrome P-450 and block the biosynthesis of estrogen, which is the main chemical Book factor to stimulate the growth of breast cancer cells. The IC50 value of this product to human placenta aromatase was 15 nmol / L. Letrozole is suitable for postmenopausal advanced breast cancer. It is mainly used for second-line treatment after failure of anti estrogen treatment
Aprepitant
Arepidem is used in combination with other antiemetic drugs to prevent acute or delayed nausea and vomiting during the initial or repeated treatment of high or moderate vomiting tumor chemotherapy. It has now been approved in more than 75 countries. The drug blocks the action of substance P by binding with NK-1 receptor (mainly in the central nervous system and its periphery), and it can occupy the NK-1 receptor in the brain through the blood-brain barrier, with high selectivity and affinity, but low affinity for NK-2 and nk-3 receptor. At the same time, the affinity of other drugs (such as dopamine receptor, 5-HT receptor) used to treat chemotherapy-induced nausea and vomiting symptoms is also very low, and the effect of reducing nausea and vomiting is better than other drugs.
Axitinib
Acitinib is used to treat advanced renal cancer (RCC) that does not respond to other drugs. Renal cell carcinoma is a kind of tumor originated from renal tubular endothelial cells. Acitinib blocks the action of certain proteins called kinases that play a role in tumor growth and metastasis. Acetinib is a small molecule tyrosine kinase inhibitor, which is effective for many targets, including VEGF receptor 1, 2 and 3.
Bicalutamide
It is soluble in dimethylformamide, tetrahydrofuran, ethyl acetate and methanol, and insoluble in water. Bicalutamide is a non steroidal androgen antagonist, competing with androgen for androgen receptor, blocking the uptake of androgen by cells, inhibiting the combination of androgen and target organs. After binding with androgen receptor, bicalutamide can form receptor complex, enter the nucleus and bind with nucleoprotein, thus inhibiting the growth of tumor cells. Bicalutamide can be used as palliative treatment for advanced prostate cancer First line medication.
Bms 582664
It is an investigational, anti-tumorigenic drug for oral administration. The drug is being developed by Bristol-Myers Squibb for the treatment of hepatocellular carcinoma or HCC (also called malignant hepatoma), the most common type of liver cancer. Hepatocellular carcinoma is a primary cancer of the liver and is more common in men than in women. The disease occurs mostly in people who have scarring of the liver (cirrhosis) or after infection with hepatitis B or hepatitis C. Symptoms include pain and swelling in the abdomen, weight loss, weakness, loss of appetite and nausea. Hepatocellular carcinoma is a severe and life-threatening disease that is associated with poor overall survival. [2] While the choice of treatment depends mainly on how advanced the disease is, the only proven therapies to cure the cancer is surgery to remove the tumor and liver transplantation, but these therapies can only be carried out in very few patients. Other treatments include chemotherapy andimmunotherapy. Radiofrequency ablation and ethanol injection are also used to remove small tumors.
Bortezomib
Bortezomib, also known as bortezomib, is a kind of hematopoiesis system cancer treatment drug. It is white or almost white crystal powder, soluble in dimethyl sulfoxide, ethanol and water solution. It is a reversible inhibitor of 26S proteasome chymotrypsin like activity in mammalian cells. 26S proteasome is a large protein complex, which can degrade ubiquitin. The ubiquitin channel plays an important role in regulating the concentration of specific proteins in the cell to maintain the stability of the cell environment. Proteolysis will affect the multi-level signal tandem in cells, which will damage the normal cell environment and lead to cell death. The inhibition of 26S proteasome can prevent the hydrolysis of specific protein. In vitro experiments showed that bortezomib was cytotoxic to many types of cancer cells. The results of preclinical tumor model in vivo showed that bortezomib can delay the growth of tumor including multiple myeloma, and it is suitable for the treatment of multiple myeloma.
Bosutinib
Bosudinib is a powerful protein kinase inhibitor, which can not only inhibit the spontaneous phosphorylation of Src protein in a variety of human tumor cells, but also inhibit the phosphorylation process of SRC and Ab1 substrates. Non receptor tyrosine kinase SRC is a member of the Src kinase family SFKs. Its function mainly regulates different signal transduction pathways triggered by various surface receptors, such as tyrosine kinase receptor, G protein coupled receptor and antigen receptor. The expression or activity of this enzyme is closely related to the metastasis, development and spread of cancer cells.
Buserelin
Bucherelin, GnRH analog. At the initial stage of use, the secretion of LH, FSH and sex hormone increased. After 1-2 weeks, the secretion of sex hormone decreased to castration level. It is mainly used in prostate cancer and breast cancer. Subcutaneous injection [with flutamide in men] was used at the beginning, while nasal injection was used for maintenance treatment.
