Pharmaceutical Chemicals API (267)
Showing 61–72 of 267 products · Page 6 of 23
Crizotinib
Crizotinib (trade name Xalkori, Pfizer), is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor, approved for treatment of some non-small cell lung carcinoma (NSCLC) in the US and some other countries, and undergoing clinical trials testing its safety and efficacy in anaplastic large cell lymphoma, neuroblastoma, and other advanced solid tumors in both adults and children.
D Cloprostenol Sodium
Cloprostenol sodium is a synthetic analogue of dinoprost (prostaglandin F2a). It is used as a luteolytic agent in veterinary medicine. Many animal producers are using cloprostenol sodium to shorten cycle or induce animal to come into heat period. Cloprostenol sodium can help animal producers improve production efficiency and economic returns.
D-cycloserine
D-cycloserine is a colorless solid that is produced by some bacteria. It is an antibiotic effective against Mycobacterium tuberculosis. Since the discovery that cycloserine is able to penetrate into the central nervous system, numerous studies have been conducted to assess the efficacy of cycloserine for psychiatric disorders. It has been found to be effective in the treatment of some neurological disorders, due to its effect as a selective partial agonist of the N-methyl-D-aspartic acid (NMDA) glutamatergic receptors found in the basolateral nucleus of the amygdala. Specifically, cycloserine affects the glycine-binding sites which are important for opening these NMDA channels. Cycloserine is stable under basic conditions, with the greatest stability at pH = 11.5.
Dactinomycin
Bright red crystalline powder, hygroscopic, gradually lost activity under light. Specific rotation [α] 18d-315 ° (0.02%, methanol). Insoluble in petroleum chemical Book ether, slightly soluble in water, soluble in methanol, ethanol and ethyl acetate, easily soluble in benzene, chloroform and acetone. Extremely toxic, LD50 (rat, oral) 7200 μ g / kg. It is effective in the treatment of malignant hydatidiform mole, nephroblastoma, Hodgkin's disease, testicular tumor, rhabdomyosarcoma, neuroblastoma and reticulosarcoma. With cervical cancer, ovarian cancer, breast cancer and gastrointestinal cancer, there are also some curative effects. Combined with radiotherapy can improve the sensitivity of radiotherapy.
Darunavir
Darunavir (formerly known as TMC114) is a protease inhibitor medication used to treat HIV infection. Darunavir is an OARAC recommended treatment option for treatment-naïve and treatment-experienced adults and adolescents.
Darzalex
On November 16, 2015, the us FDA approved the release of Daratumumab, a new monoclonal antibody drug made by Janssen and marketed under the trade name Darzalex. Clinical use of multiple myeloma after treatment with protease inhibitors and immunosuppressive agents. The bioengineered drug is an anti-cd38 monoclonal antibody that targets a transmembrane extracellular enzyme CD38 molecule highly expressed on the surface of multiple myeloma cells and can induce rapid death of tumor cells through a variety of mechanisms. Because healthy cells and all myeloma cells express CD38, adequate evaluation of drug toxicity and therapeutic efficacy is required.
Daunorubicin Hydrochloride
Orange red crystalline powder was obtained from ethanol. [α] D20-50 ° (C = 0.2, water). UV maximum absorption (methanol): 232.5253480495nm (ε 40225353001048010300). Acute toxicity LD50 mice (mg / kg): 13.66 subcutaneous injection, 4.42 intraperitoneal injection, 8.50 intravenous injection. It is a semi synthetic anti-tumor antibiotic similar to positive dinomycin, and its curative effect is similar to that of adriamycin. It is used for the remission of acute lymphoblastic leukemia and acute primordial leukemia, especially acute monocytic leukemia.
Decitabine
It is a kind of natural adenosine analogue of 2 ′ - deoxycytidine acid. It can inhibit the proliferation of tumor cells and prevent the occurrence of drug resistance by inhibiting DNA methyltransferase and reducing DNA methylation. It is the most powerful specific inhibitor of DNA methylation, belonging to S-phase cell cycle specific drug, and is suitable for the treatment of myelodysplastic syndrome (MDS).
Denatonium Benzoate Anhydrous
Benzenediammonium is a quaternary ammonium salt formed by the combination of quaternary ammonium salt cations and inert anions such as benzoate ions or saccharin anions. The cation structure of the substance is similar to that of lidocaine, a local anesthetic, except that there is an additional benzyl functional group on the nitrogen atom of the amino group.
Dequalinium Chloride
Dequalinium chloride is a selective blocker of apamin-sensitive K+ channels and inhibitor of XIAP (X-linked inhibitor of apoptosis protein). The compound has induced apoptosis in leukemia B4 cells through disturbance of mitochondrial function, oxidative stress, and downregulation of Raf/MEK/ERK and PI3K/Akt signaling pathways.
Diacetoxyiodo
Multifunctional oxidation and acetification reagents; stoichiometric oxidant in tempo oxidation of neritol to nerolaldehyde; oxidant in rhodium catalyzed acridine reaction of alkene with sulfamate; 2-arylation of indole catalyzed by palladium at room temperature; reagents for synthesis of various heterocyclic compounds; Vic glycol cracking agent, hydroxylation and many oxidation reactions It is used for the preparation of thermal labile substance iodobenzene.
