Zoledronic Acid Hydrate
Also known as: ZoledronicacidforInjection
Azole phosphonic acid is a kind of specific effect on bone diphosphate compounds, it inhibits by osteoclasts activity increased bone resorption. Diphosphate compound effect on bone tissue selectivity depends on its high affinity of mineralized bone role of molecular mechanism is unclear. Long-term animal studies have shown that azole phosphonic acid can inhibit bone absorption, but for the formation of bone, bone mineralization and mechanical characteristics of no bad influence, in the initial 24 hours, dosage of 44 plus or minus 18% excretion in the urine, the rest of the main stranded in the bone tissue. Azole phosphonic acid and blood no affinity, and the combination of plasma protein is low (about 22%), and is not dependent on the azole phosphonic acid concentration, the injection time increased from 5 minutes to 15 minutes, at the end of the injection, azole phosphonic acid concentration was reduced by 30%, but has no effect on AUC .
| Payment & Shipping Terms | Supply Capacity | ||
|---|---|---|---|
| Payment Terms: | T/T, WU | Production Capacity: | 1000kg/year |
| Min. Order: | 1 Gram | Packing: | according to the customer's requirements |
| Means of Transport: | Ocean, Air, Land | Delivery Date: | 7 days |
Zoledronic Acid Hydrate
CAS 165800-06-6
Azole phosphonic acid is a kind of specific effect on bone diphosphate compounds, it inhibits by osteoclasts activity increased bone resorption. Diphosphate compound effect on bone tissue selectivity depends on its high affinity of mineralized bone role of molecular mechanism is unclear. Long-term animal studies have shown that azole phosphonic acid can inhibit bone absorption, but for the formation of bone, bone mineralization and mechanical characteristics of no bad influence, in the initial 24 hours, dosage of 44 plus or minus 18% excretion in the urine, the rest of the main stranded in the bone tissue. Azole phosphonic acid and blood no affinity, and the combination of plasma protein is low (about 22%), and is not dependent on the azole phosphonic acid concentration, the injection time increased from 5 minutes to 15 minutes, at the end of the injection, azole phosphonic acid concentration was reduced by 30%, but has no effect on AUC .
We can customize according to customer's requirement
if you have any question pls mail us or call us.
| CAS Number | 165800-06-6 |
|---|---|
| Molecular Formula | C5H12N2O8P2 |
| Place of Origin | Zhejiang,China (Mainland) |
| Brand | MOSINTER |
| CAS | 165800-06-6 |
Send an inquiry for Zoledronic Acid Hydrate
Related products
1-Bromo-3-chloro-2-methylpropane
Application:Used as pharmaceutical intermediates
1-benzyl-2-phenyl-1H-imidazole
Contact MOSINTER for product specifications and supply information.
10-Hydroxycamptothecin
Exemestane is an irreversible steroidal aromatase inhibitors, has similar structure with its substrate,natural androstenedione. And it is the pseudo substrate of aromatase . The inhibition of aromatase to estrogen deprivation is a effective method in the treatment of postmenopausal women with hormone dependent breast cancer.
2-Chlorophenothiazine
Application:Chlorpromazine hydrochloride used as drug intermediates; Pharmaceutical intermediates for the preparation of chlorpromazine, perphenazine.
3-Dimethylamino-2-methylpropyl Chloride Hydrochloride
Application:Used as pharmaceutical intermediates
3-Dimethylaminopropylchloride Hydrochloride
1. Used for synthesis of chlorpromazine, doxepin hydrochloride, chlorprothixene medicine, etc
3-Ethyl-4-methyl-3-pyrrolin-2-one
3-Ethyl-4-methyl-3-pyrrolin-2-one, a five-membered α,β-unsaturated lactam derivative, has various applications in medicinal chemistry. It can be synthesized by employing following as starting materials:[1] • allylamine, via palladium(II)-assisted cyclization • 4-methoxybenzylamine, via a ring-closing-metathesis strategy • 3-ethyl-1-(4-methoxybenzyl)-4-methyl-1,5-dihydro-2H-pyrrol-2- one
5- 1-Hydroxyl-1-methylethyl -2-propyl-imidazol-4-yl Carboxylic Acid Ethyl Ester
[5-(1-Hydroxyl-1-methylethyl)-2-propyl-imidazol-4-yl]carboxylic acid ethyl ester
