Isoniazid
Also known as: Isonicotinic Acid Hydrazide
Isoniazid is an antibacterial agent used primarily as a tuberculostatic. Target: Antibacterial Isoniazid is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme that in M. tuberculosis is called KatG. KatG couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This process inhibits the synthesis of mycolic acid, required for the mycobacterial cell wall. A range of radicals are produced by KatG activation of isoniazid, including nitric oxide, which has also been shown to be important in the action of another antimycobacterial prodrug PA-824. Isoniazid is bactericidal to rapidly dividing mycobacteria, but is bacteriostatic if the mycobacteria are slow-growing.
| Payment & Shipping Terms | Supply Capacity | ||
|---|---|---|---|
| Payment Terms: | T/T, WU | Production Capacity: | 1000kg/year |
| Min. Order: | 1 Gram | Packing: | According to the customer's requirements |
| Means of Transport: | Ocean, Air, Land | Delivery Date: | 7 days |
Isoniazid
CAS 54-85-3
Isoniazid is an antibacterial agent used primarily as a tuberculostatic. Target: Antibacterial Isoniazid is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme that in M. tuberculosis is called KatG. KatG couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This process inhibits the synthesis of mycolic acid, required for the mycobacterial cell wall. A range of radicals are produced by KatG activation of isoniazid, including nitric oxide, which has also been shown to be important in the action of another antimycobacterial prodrug PA-824. Isoniazid is bactericidal to rapidly dividing mycobacteria, but is bacteriostatic if the mycobacteria are slow-growing.
We can customize according to customer's requirement.
If you have any question pls mail us or call us.
| CAS Number | 54-85-3 |
|---|---|
| Molecular Formula | C6H7N3O2 |
| Molecular Weight | 153.1387 |
| Place of Origin | Zhejiang,China (Mainland) |
| CAS NO. | 54-85-3 |
| Melting point | 170-174℃ |
| EINECS | 200-214-6 |
| Fp | >250°C |
| Refractive index | 1.577 |
| Water solubility | 14 g/100 mL (25℃) |
Send an inquiry for Isoniazid
Related products
1-Bromo-3-chloro-2-methylpropane
Application:Used as pharmaceutical intermediates
1-benzyl-2-phenyl-1H-imidazole
Contact MOSINTER for product specifications and supply information.
10-Hydroxycamptothecin
Exemestane is an irreversible steroidal aromatase inhibitors, has similar structure with its substrate,natural androstenedione. And it is the pseudo substrate of aromatase . The inhibition of aromatase to estrogen deprivation is a effective method in the treatment of postmenopausal women with hormone dependent breast cancer.
2-Chlorophenothiazine
Application:Chlorpromazine hydrochloride used as drug intermediates; Pharmaceutical intermediates for the preparation of chlorpromazine, perphenazine.
3-Dimethylamino-2-methylpropyl Chloride Hydrochloride
Application:Used as pharmaceutical intermediates
3-Dimethylaminopropylchloride Hydrochloride
1. Used for synthesis of chlorpromazine, doxepin hydrochloride, chlorprothixene medicine, etc
3-Ethyl-4-methyl-3-pyrrolin-2-one
3-Ethyl-4-methyl-3-pyrrolin-2-one, a five-membered α,β-unsaturated lactam derivative, has various applications in medicinal chemistry. It can be synthesized by employing following as starting materials:[1] • allylamine, via palladium(II)-assisted cyclization • 4-methoxybenzylamine, via a ring-closing-metathesis strategy • 3-ethyl-1-(4-methoxybenzyl)-4-methyl-1,5-dihydro-2H-pyrrol-2- one
5- 1-Hydroxyl-1-methylethyl -2-propyl-imidazol-4-yl Carboxylic Acid Ethyl Ester
[5-(1-Hydroxyl-1-methylethyl)-2-propyl-imidazol-4-yl]carboxylic acid ethyl ester
