Isoniazid
Also known as: Isonicotinic Acid Hydrazide
Isoniazid is an antibacterial agent used primarily as a tuberculostatic. Target: Antibacterial Isoniazid is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme that in M. tuberculosis is called KatG. KatG couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This process inhibits the synthesis of mycolic acid, required for the mycobacterial cell wall. A range of radicals are produced by KatG activation of isoniazid, including nitric oxide, which has also been shown to be important in the action of another antimycobacterial prodrug PA-824. Isoniazid is bactericidal to rapidly dividing mycobacteria, but is bacteriostatic if the mycobacteria are slow-growing.
| Payment & Shipping Terms | Annual Production Capacity | ||
|---|---|---|---|
| Payment Terms: | T/T, WU | Annual Production Capacity: | 1,000 MT/year |
| Min. Order: | 1 Gram | Packing: | According to the customer's requirements |
| Means of Transport: | Ocean, Air, Land | Delivery Date: | 7 days |
Isoniazid
CAS 54-85-3
Isoniazid is an antibacterial agent used primarily as a tuberculostatic. Target: Antibacterial Isoniazid is a prodrug and must be activated by a bacterial catalase-peroxidase enzyme that in M. tuberculosis is called KatG. KatG couples the isonicotinic acyl with NADH to form isonicotinic acyl-NADH complex. This complex binds tightly to the enoyl-acyl carrier protein reductase known as InhA, thereby blocking the natural enoyl-AcpM substrate and the action of fatty acid synthase. This process inhibits the synthesis of mycolic acid, required for the mycobacterial cell wall. A range of radicals are produced by KatG activation of isoniazid, including nitric oxide, which has also been shown to be important in the action of another antimycobacterial prodrug PA-824. Isoniazid is bactericidal to rapidly dividing mycobacteria, but is bacteriostatic if the mycobacteria are slow-growing.
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| CAS Number | 54-85-3 |
|---|---|
| Molecular Formula | C6H7N3O |
| Molecular Weight | 137.14 |
| Place of Origin | Zhejiang,China (Mainland) |
| CAS NO. | 54-85-3 |
| Melting point | 170-174°C |
| EINECS | 200-214-6 |
| Fp | >250°C |
| Refractive index | 1.577 |
| Water solubility | 14 g/100 mL (25°C) |
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